4Sleep

Effective combination of 4 well studied natural active ingredients, in a unique formula, to promote a high quality sleep.

4Sleep is a concentrated formula that contains the correct amounts of pure melatonin, 5-HTP (99%) from Griffonia Simplicifolia seed extract, valerian root extract and chamomile flower extract.

All of these ingredients were selected to present a synergetic effect to combat insomnia, improve sleep quality and decrease stress levels and anxiety over the day. The synergetic effect happens when the selected ingredients in a formulation are able to empower each other in a way that is greater than the sum of activity had they been given separately.  

Melatonin is the main hormone involved in the regulation of body’s bio clock and sleep-wake cycles. When administered orally, it helps induce sleep in people with insomnia, diminishes sleep disorders related to jet lag, shifts, menopause, high blood pressure problems, attention deficit hyperactivity disorders (ADHD) and circadian rhythm disorders in blind people.

Melatonin contributes to the alleviation of subjective feelings of jet lag. The beneficial effect is obtained starting with a minimum intake of 0.5 mg to be taken close to bedtime on the first day of travel and on the following few days after arrival at the destination.
Melatonin contributes to the reduction of time taken to fall asleep. The beneficial effect is obtained by consuming 1 mg of melatonin close to bedtime.

4Sleep contains 1 mg of melatonin per capsule.

Another active ingredient of 4Sleep is 5-HTP (99%) from Griffonia Simplicifolia seed extract (25:1). 50 mg of this extract are equivalent to 1.25 g of dried griffonia seeds per capsule.

5-HTP helps the body to produce more serotonin (the “happiness” hormone) a neurotransmitter that plays a key role in regulating mood, promoting restful sleep, appetite control and increased sexual desire. Together with the neurotransmitters dopamine and noradrenaline, it participates in the mechanisms that govern anxiety, fear, anguish and aggressiveness.

Research has shown that 5-HTP may reduce the risks of panic attacks, as well as anxiety and emotional stress and may be effective in helping to alleviate depression.

4Sleep contains 110 mg of valerian root extract (3:1), which is equivalent to 330 mg of dried valerian root per capsule.

Valerian root has been used for centuries as a remedy for anxiety, nervousness and sleep disorders. Scientific studies suggest that it increases the levels of a chemical known as gamma aminobutyric acid (GABA) in the brain. GABA reduces the activity of neurons in the brain and central nervous system, increasing relaxation, reducing stress and shortening the time to fall asleep. 

The key advantage of valerian is its capability to induce the slow wave sleep. Slow-wave sleep refers to phase 3 sleep that is the deepest state of NREM sleep. It is the constructive phase of sleep for recuperation of the mind-body system in which it rebuilds itself after each day.

4Sleep contains 110 mg of chamomille flowers extract (4:1), which is equivalent to 440 mg of dried chamomille flowers per capsule.

Chamomile is a traditional herbal medicine that has actually been used over thousands of years to treat many different ailments, including insomnia. Apigenin is a bioflavonoid very abundant in chamomile’s flowers, constituting 68% of total flavonoids. It exerts sedative and anxiety-reducing effects, along with muscle-relaxing effects, due to its connection to benzodiazepine receptors in the brain.

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